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Research into Allopregnanolone
03/14/2025

This was heavy on the science, but offers some interesting insight into how hormone conversions can affect us as we age.

Take a look at our 'ELI5' (Explain Like I'm 5)  breakdown!

Okay, imagine your body is like a little factory that makes special chemicals to help you feel good and stay balanced. Two of these chemicals are called progesterone and allopregnanolone—but let’s call them "P" and "A" to keep it simple.

Here’s what’s going on:

  1. P (Progesterone) is like the main ingredient.
  2. A (Allopregnanolone) is made from P, and it helps your brain feel calm and happy.
  3. Scientists wanted to see how much P and A your body makes at different times in a woman’s monthly cycle.
  4. They checked women before menopause and after menopause.

What did they find?

In younger women, as they moved through their cycle:

    • P went up (more main ingredient).
    • A went up (more calming stuff).
    • But A didn’t go up as much as P—so the amount of A compared to P actually went down.

Think of it like making cookies. You start with a little dough (P) and get a few cookies (A). Later, you have a LOT of dough (P), but you only make a few more cookies (A). So, the cookie-making doesn’t keep up with the dough. In older women (after menopause):

    • P and A were both lower all the time (less dough, fewer cookies).
    • But the balance between A and P was kind of the same as at the beginning of the younger women’s cycle.

Why does this matter?

Scientists think A (the calming stuff) might help with mood. If your A is low compared to your P, it could maybe make you feel more anxious or sad. This might help explain why some women feel moody at certain times in their cycle or after menopause.

Link: https://www.sciencedirect.com/science/article/abs/pii/S0306453019312533