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How Cortisol Affects the Gut
02/11/2025

This study explored how constipation and diarrhea severity during the menopause transition (MT) relate to age, MT stage, reproductive and stress-related biomarkers, and stress perceptions.

Methods: Women aged 35-55 were followed from 1990 to 2013, with data collected annually through health diaries, questionnaires, and urine samples. These samples were tested for hormones like E1G, FSH, testosterone, cortisol, and others. Researchers used statistical modeling to see how changes in constipation and diarrhea were related to these factors.

Results:

  • Constipation: Age, being in the late reproductive stage, and stress (tension and anxiety) were linked to increased severity of constipation. However, cortisol (a stress hormone) was negatively associated with constipation. After adjusting for other factors, only tension and cortisol remained significant predictors of constipation severity.
  • Diarrhea: Age and certain hormones were linked to reduced diarrhea severity, while stress and anxiety were associated with more severe symptoms. In the final model, tension and age were the main predictors of diarrhea severity.

Conclusions: Reproductive hormones had little impact on constipation or diarrhea during menopause, but stress, including tension, anxiety, and cortisol levels, played a significant role. The study suggests these stress factors should be studied more in relation to digestive issues during menopause.

Link: https://journals.lww.com/menopausejournal/abstract/2018/06000/constipation_and_diarrhea_during_the_menopause.9.aspx