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Hormones After Hysterectomy
02/28/2024

This study explored how hysterectomy and oophorectomy affected androgen levels before and after menopause. They found that, "the postmenopausal ovary remains a critical source of androgen throughout the lifespan of older women."

What does this mean for women in menopause? Let's look at the science!

"The reduction in testosterone levels in intact women during early postmenopause and the sustained reduction of both total and bioavailable testosterone in bilaterally oophorectomized women of all ages may have important clinical significance, especially for skeletal health. Androgens inhibit bone resorption as well as increasing bone formation (50, 51), and low levels of endogenous testosterone have been reported to correlate with fractures in elderly women (52, 53). During the perimenopause, women with higher testosterone concentrations have slower rates of bone loss than those with lower concentrations independent of their estrogen status (54). Clinical trials have shown that androgens act synergistically with estrogens in surgically and naturally menopausal women to relieve vasomotor symptoms, increase bone mineral density, and enhance libido, well-being, and energy level (55–60). Although further studies are needed, the testosterone data from this study may help in determining whether, when, and for how long androgen replacement should be recommended for menopausal women."

This suggests that, unless medically necessary, the ovaries should remain, given their role in hormone production and overall health.

Link: https://academic.oup.com/jcem/article/85/2/645/2854045